![]() Different lymph node size has a different number of lobules. The fibrous capsule extends into the lymph node to form trabeculae and divide each node into lobules. A tough fibrous connective tissue capsule encapsulates lymph nodes. Lymph nodes play a vital role in the body’s ability to fight off infection. This will be achieved through clinical trials conducted in collaboration with medical professionals, aiming to validate the effectiveness of these approaches in cancer patients.Lymph nodes are small, round kidney-shaped structures that run with the lymphatic system. Looking ahead, the research team aims to further investigate the LDDS with the goal of enhancing therapeutic responses against lymph node metastasis. Meanwhile, Kodama says, "LDDS offers a novel, safe method for delivering anticancer drugs to susceptible LNs, presenting a promising approach for improving cancer treatment effectiveness while minimizing side effects." "This approach provides a safer alternative to LN removal and promises to improve cancer survival rates." "LDDS is a groundbreaking method to improve treatment while decreasing side effects," says Ariunbuyan Sukhbaatar, assistant professor at the Graduate School of Dentistry and lead author of the paper. The research team emphasizes the safer nature of the new method. Histopathological assessments confirmed the efficacy, highlighting the potential of LDDS in cancer management. The double-shot administration enhanced T helper cell differentiation in the spleen and sentinel LNs, emphasizing its potential in cancer management. Their findings confirmed superior therapeutic outcomes, increased complete response, improved survival, and reduced adverse complications. ![]() To test this hypothesis, Kodama and his team administered the treatment to a preclinical model of a metastatic lymph node mouse model. Based on this, they hypothesized that administering docetaxel - a widely used clinical anticancer drug - through LDDS at an osmotic pressure and viscosity of 1,960 kPa and 12 mPa∙s would result in superior antitumor effects, prolonged survival, and minimal adverse reactions. In a prior investigation, some of the current researchers utilized LDDS incorporating heightened osmotic pressure and viscosity of docetaxel, yielding promising outcomes in the treatment of early-stage LN metastasis during preclinical research. Most commonly, some individuals experience uncomfortable side effects that gradually diminish over time. In fact, two individuals undergoing the same treatment may encounter markedly different experiences. Still, the occurrence of side effects can differ from individual to individual and from one treatment to another. Thus, there is a need for improved control of LN metastasis without surgical or radiation interventions. ![]() They are the initial lymph nodes that receive drainage from a primary tumor and indicate that metastasis has begun or could potentially occur. Recent research has highlighted sentinel LNs as the gateway for metastasis. Professor Tetsuya Kodama from Tohoku University's Graduate School of Engineering led the research team. Details of the researchers' breakthrough were published in the journal Biomedicine & Pharmacotherapy on January 2, 2024.
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![]() We expect commenters to treat each other and the blog writers with respect. We review all comments before they are posted, and we won’t post comments that don’t comply with our commenting policy. But keep in mind, this is a moderated blog. Your thoughts, ideas, and concerns are welcome, and we encourage comments. The purpose of this blog and its comments section is to inform readers about Federal Trade Commission activity, and share information to help them avoid, report, and recover from fraud, scams, and bad business practices. If this happens to you, please report it at. There may be tens of thousands of victims, and only a small fraction report it to the FTC. ![]() Unfortunately, online dating scams are all too common. If your online sweetheart asks for money, you can expect it’s a scam. Here’s the real deal: Don’t send money to someone you met online - for any reason. And if the person’s online profile disappears a few days after they meet you, that’s another tip-off. wire money using Western Union or Money Gramĭid you know you can do an image search of your love interest’s photo in your favorite search engine? If you do an image search and the person’s photo appears under several different names, you’re probably dealing with a scammer.chat off of the dating site immediately, using personal email, text, or phone.Here are some warning signs that an online love interest might be a fake. Victims think they’re just helping out their soulmate, never realizing they’re aiding and abetting a crime. The scammers transfer stolen money into the new account, and then tell their victims to wire the money out of the country. After they form a “relationship,” they come up with reasons to ask their love interest to set up a new bank account. Here’s how it works: The scammers set up dating profiles to meet potential victims. Why all of the tricks? They’re looking to steal your money.Īs if all that isn’t bad enough, romance scammers are now involving their victims in online bank fraud. They profess their love quickly. And they tug at your heartstrings with made-up stories about how they need money - for emergencies, hospital bills, or travel. Scammers create fake online profiles using photos of other people - even stolen pictures of real military personnel. Not everyone using online dating sites is looking for love. Identity Theft and Online Security Show/hide Identity Theft and Online Security menu items.Unwanted Calls, Emails, and Texts Show/hide Unwanted Calls, Emails, and Texts menu items.Money-Making Opportunities and Investments.Jobs and Making Money Show/hide Jobs and Making Money menu items.Credit, Loans, and Debt Show/hide Credit, Loans, and Debt menu items.Shopping and Donating Show/hide Shopping and Donating menu items. ![]() Why then do you not speak in the Common Tongue,Īs is the custom in the West, if you wish to be answered? For example: Actor 1: Well do I understand your speech, yet few strangers do so. The followingĪegisub also supports importing "dialogue-formatted" plain text scripts. Loading subtitles directly from Matroska files can also be done. Plain "dialog script" formatted text (see below).MPEG4 Timed Text (limited support at best broken at worst), also known as. ![]() ![]() Advanced Substation Alpha, also known as SSA v4+ (.ass).Looks garbled or otherwise incorrect, try reopening it with another characterĪegisub supports reading the following subtitle formats: Will ask you to choose from two or more likely alternatives. When you open a subtitles file that is not detected as Unicode, Aegisub willĪttempt to guess what character set it is encoded with. Open subtitles from video - Open the subtitles muxed into the currently.If you have a file in an unusual charset Aegisub will occasionally misdetect Open subtitles with charset - Opens subtitles but lets you choose whatĬharacter set Aegisub will use to interpret the file.Open subtitles - Opens an existing subtitles file or imports subtitles.New subtitles - Creates a new, blank script.In the File menu, there are four menu choices that relate to opening or **Todo:** This page should probably be split into several smaller ones to make it easier to digest, easier to link, less confusing and wall-of-text and to promote going more in depth with the separate topics. ![]() It’s user-friendly and ensures privacy by automatically deleting uploads after an hour. TinyWow is a versatile website offering a range of PDF editing tools, including text editing, signature addition, and page manipulation. It’s more suitable for users familiar with advanced image editing tools. Inkscape is an image editor that surprisingly supports PDF editing, particularly useful for manipulating graphics and text in PDFs. It’s a good option for users who need advanced features occasionally. While using non-free features results in a watermark, its free functionalities are quite comprehensive. PDF-XChange Editor offers a mix of free and paid features. It’s incredibly user-friendly and ad-free, making it perfect for quickly adding signatures to PDFs. is a straightforward tool focusing solely on PDF signing. However, it’s not ideal for documents exceeding 15 MB or 15 pages. Its integration with platforms like Google Photos enhances its usability. You can edit text, add hyperlinks, and utilize various design tools. While primarily known for graphic design, Canva also offers robust PDF editing capabilities. The Extract Text tool is particularly useful for pulling out text from difficult-to-select areas. It’s ad-free and doesn’t impose watermarks, making it a solid choice for uninterrupted editing. PDFgear is a comprehensive toolkit offering a range of functionalities, including text editing, signature and form tools, and conversion options. However, it has limitations like a three PDFs per hour cap and a maximum document size of 50 MB. It’s user-friendly and can be run entirely in your web browser, eliminating the need for downloads. Sejda PDF Editor stands out for its ability to let users edit pre-existing text in PDFs without adding a watermark – a rare feature among free PDF editors. Summary Of The Best Editors Sejda PDF Editor For free and open-source option: LibreOffice Draw.For specific tasks like merging or converting: PDF Candy or Smallpdf.For online editing and advanced features: PDFgear or DocFly.For basic editing and offline use: PDF24 Creator or Sejda PDF (desktop app).LibreOffice Draw: Free and open-source drawing tool that can also edit PDFs (desktop app).Smallpdf: Online editor with a clean interface and focus on specific tasks like merging, splitting, and compressing PDFs.PDF Candy: Web-based editor with basic editing features and document conversion tools.Limited editing features compared to othersįree (limited features), Premium plans available Powerful editing tools, no ads/watermarks, desktop appĮasy-to-use interface, online and offline editing Versatile features, document OCR, free forever Simple interface, offline editing, batch processing Here’s a comparison of some top contenders: FeatureĮdit text, add images/shapes, insert/extract pages, rotate/crop, merge/split PDFsĮdit text, add images/shapes, fill forms, sign PDFs, annotate, merge/split PDFsĮdit text/images, add/edit links, create forms, insert/extract pages, rotate/crop, merge/split PDFsĮdit text, add images/shapes, highlight/annotate, merge/split PDFs, add watermarks/signatures Best Free PDF Editors in 2024Ĭhoosing the best free PDF editor depends on your needs and priorities. Let’s explore some top choices that cater to various needs, from basic text editing to more advanced features like image manipulation and form filling. With a plethora of options available, it’s crucial to identify the best free PDF editors that combine functionality with ease of use. Finding the right PDF editor can be a game-changer in how we handle documents in our daily personal and professional lives. ![]() If so, follow the prompts to activate Microsoft 365. However, depending on your product you might see the Microsoft Office Activation Wizard. In most cases, Microsoft 365 is activated once you start an application and after you agree to the License terms by selecting Accept. Start using an Microsoft 365 application right away by opening any app such as Word or Excel. If you're unable to install Microsoft 365 see Troubleshoot installing Office for more help. For example depending on your version of Windows, select Start and then scroll to find the app you want to open such as Excel or Word, or type the name of the app in the search box. Select Close.įollow the instructions in the window to find your Microsoft 365 apps. Your install is finished when you see the phrase, "You're all set! Office is installed now" and an animation plays to show you where to find Office applications on your computer. If you see the User Account Control prompt that says, Do you want to allow this app to make changes to your device? select Yes. Remember a one-time purchase version of Microsoft 365 is licensed for one install only.ĭepending on your browser, select Open file (in Edge or Internet Explorer), Setup (in Chrome), or Save File (in Firefox). Select the tab below for the version you're trying to install. You're now ready to install Microsoft 365. Choose the language and bit version you want, and then select Install. To install Microsoft 365 in a different language, or to install the 64-bit version, use the dropdown to find more options. Sign in with the Microsoft account you associated with this version of Microsoft 365.įorgot your account details? See I forgot the account I use with Office.įrom the Overview page, select Office apps and on that page, find the Microsoft 365 product you want to install and select Install. Go to your Microsoft account dashboard and if you're not already signed in, select Sign in. Third-party seller: You bought Microsoft 365 from a third-party and you're having problems with the product key. ![]() Some organizations have different methods to install Microsoft 365 on multiple devices. Volume license versions: If you work in an organization that manages your installations, you might need to talk to your IT department. Microsoft Workplace Discount Program (formerly known as Home Use Program): If you bought Microsoft 365 for personal use through your company, see Install Office through Workplace Discount Program. Operating system: 8.Note: The steps to install the 2019, 2016, or 2013 versions of Office Professional Plus, Office Standard, or a stand-alone app such as Word or Project might be different if you got Microsoft 365 through one of the following:.To use hardware graphics acceleration, you need a graphics card that supports DirectX10. 2 GB of RAM is recommended for graphics, Outlook Instant Search, and some advanced features.x86 or 圆4 processor with a clock speed of 1 GHz and support for the SSE2 instruction set.Microsoft Office 2016-2019-2021 Professional Plus.Microsoft Office 2016-2019-2021 Edition includes Free download Microsoft Office Professional Plus 2016-2019-2021 full version offline installer for Windows PC with direct download and Torrent Magnet link. ![]() He further mentioned in a separate tweet that this security mishap might be due to Rockstar’s “work-from-home” situation with developers sharing sensitive content over the cloud. As per the sources of Bloomberg reporter Jason Schreier, who leaked the female protagonist, the leak is real. that GTA 6 Close to the door as it is now in the latest developments. Where the users of the game are in a state of waiting now that the company, Rockstar, the owner of this series of games, has released an official trailer. But, several reliable sources indicate that this leak might indeed be real, and one of the largest in video game history. How to download GTA 6 Grand Theft Auto 6 Most important leaks Download Grand Theft Auto VI new. Files for gta-6-all-leaked-gameplay-footage-grand-theft-auto-vi20220918 GTA 6 All Leaked Gameplay Footage (Grand Theft Auto VI).mp4, 1 22:44, 111.4M. And since 3080 came out in 2020, the videos have to be from 2020 or later.Īt the moment, Rockstar Games officially hasn’t confirmed or denied the truth of this massive leak. Though, several users also mentioned that the GTA 6 alpha gameplay footage’s overlay has Nvidia GeForce RTX 3080 graphics card mentioned in it. None of the leaked footage had any dates mentioned in it. They further mentioned that one main clip showed a restaurant getting looted followed by a police encounter while another showed some racist dialogues between two characters near a pool.Ī variety of users, with access to the leak, have pointed out that most of the videos in this archive appear to be from the early development stage as the textures in them are rigid and incomplete. Rockstar has acknowledged and authenticated the hack, and is working to scrub the leaked material from the internet. ![]() UPDATE 2: Video game journalist Jason Schreier who previously leaked the game’s setting and more has stated he spoke to sources inside Rockstar Games and they confirmed all of the video leaks are real.Screenshot of the post that leaked GTA 6 footageĪs per sources, some of the clips even feature billboards and vehicles with the name “Vice City” written on them. On September 18, an unprecedented GTA 6 leak saw over 90 videos and screenshots from an early, in-development alpha build of the game surface online. In the span of one day, leaks to the upcoming, much-awaited Grand Theft Auto 6 (GTA 6) were uploaded, spread, and taken down. Overall, if true, this could cause the game to be delayed even longer. UPDATE 1: Since the clips surfaced online, the leaker has now published a load of source code for Grand Theft Auto VI. A massive trove of Grand Theft Auto VI assets, including pre-alpha footage and multiple screenshots, were released to public forums early Sunday morning. For legal reasons and because we cant afford to pay Take-Two lawyers we cant post videos or pictures directly on the site, so we will only be posting tweets from other people. On a Police Car is also says V.C.P.D for Vice City Police Department, with the police force being part of ‘Port Gellhorn.’ A possible location in GTA 6. ![]() The clips also show that crouching could be making a return from GTA IV. ![]() The clips also shown some game mechanics, from driving cars, shooting a weapon, using boats and jumping. It was also pointed out, in some of the videos the Rockstar Internal development software was shown off, which is near impossible to fake, the videos also showed us a male and female main protagonist, which was leaked a few months ago. 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Some are silly (the “My Water Broke” game is sure to have everyone in hysterics), while others are downright sentimental, like guessing which family members match the baby photos and sharing fond memories of the mom-to-be. You’ll be happy to know that lots of these games are printable (so, so easy!) or can be put together in a flash (a few plastic pacifiers, and you’re good to go). That’s why we’re here with 30 unexpected baby shower games to liven up your all-things-baby shindig. If you’re planning a shower for a friend or family member, maybe you’d like to switch things up with some new baby shower ideas that guests may not see coming. We’ve all played those same games over and over again, getting out the tape to measure mom’s belly, changing diapers on dolls, and other activities you’ve come to expect. If there is a mistake made on our part, we will make an exception to this no-refund policy.Think about how many baby showers you’ve been to over the years. Look at pictures of horses, birds, butterflies, and other species. Ownership and copyright over all designs and graphics contained in the files are property of .ĭue to the digital nature of this product, all sales are final. Thats why all children will benefit from a Baby Animal game online. You may not copy, reproduce, share, or transfer any of the files or graphics to a third-party. The printed colors may vary from the photos depending on your printer's quality and settings. List of Animals Baby Name in English Male, Female, and their Baby Name List List of Animals Baby Name in English. This exercise will help them to expand their vocabulary as well as their knowledge of the. This picture card activity will help your child to identify and name both animals and their baby young, just like this animal chart with pictures. Here, We have provided a common animal baby name in English. Your kids must match up the animal with its baby, as well as using the correct vocabulary when doing so. You can print them at home or use a printing service. Learn different types of animals and their babies name in English with pictures. The animal pairs included in this resource are as follows: turkey & poult, chicken & chick, duck & duckling, horse & foal, cat and kitten, goat & kid, pig & piglet, sheep & lamb, cow & calf, dog & puppy. I recommend printing on white card stock that is 8.5 x 11 inches. Print, cut and enjoy! Print as many copies as you need. On a PC computer right click on the zip file and go to ”extract all”.ģ. On a Mac double click on the zip file and it will open your files. Preschool and F-2 youngsters can learn about plenty of amazing species - from elephants to frogs - with this teacher-made worksheet. ![]() Please note that your files may come in a zip format. Help your little animal lovers to match the adult animal to its offspring with this baby animal worksheet. Files are not recommended to be saved/opened with Tablets, Smartphones, iPads or iPhones. Once payment is complete, your files will be sent to you via email. Which means no physical product will be shipped to you. It includes 22 different animals, all using real photographs Here are a few more to peek at. **This listing is for a digital file ONLY. 2 game cards (5x7" inches) on 8.5x11" page With two game sizes, you will be able to print the game cards exactly how you need them. After they finish matching, ask them to write the names. You might also like this Animals and their Babies Worksheet. Remember that pictures and drawings are still abstractions: they are two-dimensional representations of something real. Try laying out cards with matching pairs (animals, faces, flowers). ![]() For instance, matching a dog with a puppy and a horse with its foal. Starting at 19 months and continuing well into their 2s, your toddler will begin to learn about picture matching. Your students must match up the animal with its baby, as well as using the correct vocabulary when doing so. This fantastic baby farm animals matching activity gets children to match up pictures of mothers with their young. Your guests will enjoy testing their knowledge to see who can guess all the correct names of the baby animals. Invite children to use scissors to cut out the baby animal pictures and match them to their mothers. Choose from two sets of matching cards - some with the names of the animals and their young, and some without. Load these pictures into your tray to recreate and customize this material. A fun baby shower game that you can download instantly and print yourself! ![]() But there is hope yet! At CppCon 2023, CMake’s Bill Hoffman and Bloomberg’s Bret Brown talked about the initial standard for dependency management in C++ – metadata files to describe pre-built libraries. This comes from the fact that C++ libraries are difficult to define, and using them in a pre-built form is tricky. In the C++ Foundation Annual C++ Developer Survey “Lite”, this peeve took first place and was named a “major pain point” by 47% of the respondents. ![]() Managing third-party libraries is one of the biggest challenges in C++, even after 35 years of its existence. (By the way, did you know Android Studio uses CLion’s C++ support? It builds a proprietary component on top of our source code.) We are happy to be part of this competition to evolve and deliver the best experience to our users. In terms of full-featured IDEs, CLion and Visual Studio occupy comparable positions on the market, with Visual Studio Code rivaling them as a smart editor. Most C++ developers seem to be sticking with the same few IDEs and editors: What’s your take on that?Ĭ++ tooling: The major players remain unchanged Most surveys and GitHub scans indicate no more than 5%–10%, even though big companies like Google are known to be migrating parts of their huge code bases to Rust for security and safety reasons. We’d love to know how many Rust projects are currently utilizing C++ and vice versa. sln files with Python.Īs for Rust, there is an interesting question we’re now looking into with the JetBrains RustRover team. ![]() In my C++ development experience, Python was also widely used for wrapping the project model, and I know many game development studios that still process their. In 2023, Python is still there with a clear lead over C: This phenomenon is not new and has a lot to do with the need to use old compiler versions, especially in some embedded projects.įun fact: Last year, I managed to surprise Jason Turner by revealing that Python is the number one companion to C++ developers after C++ itself. The share of those who don’t plan to migrate to the newer standards hovers around 50%, with the highest figure (57%) coming from those who still use C++98/C++03. C++23 started off with 10% this year, so now all bets are on what share it will reach in 2024.We also looked back and compared the recent language standards on their shares of adoption in the first year of release vs. By the way, did you know that Unreal Engine emulates reflection via macros? This trend is likely to be amplified when the language adds reflection – one of the most-awaited language features for game developers in view of its high importance for object serialization algorithms. ![]() It seems like the gamedev industry is ahead of the game in adopting newer C++ standards. Part of the driving force behind this is that C++ conferences have been tending to favor talks about C++20 and C++23. Next year, we could realistically see the combined share of C++20 and C++23 surpassing that of C++17. The downside trends for C++11 and C++14 continue, and C++17 demonstrates only tiny growth as people migrate to C++20 and C++23. Diego Rodriguez-Losada Gonzalez, Lead Architect at JFrog, the team behind Conan.Bryce Adelstein Lelbach, Principal Architect at NVIDIA.Inbal Levi, Lead Software Engineer at MPGC Services Ltd (Millennium), WG21 committee member.We are grateful to them for their thoughts on our data and findings: We also asked several community members to chime in with their comments, including renowned experts representing the language committee and companies that play a significant role in the evolution of C++. We scrutinized the raw data to extract valuable insights and share them with you. Among them, 2,627 indicated C++ as one of their top three primary languages. In 2023, we collected 34,493 responses from software developers worldwide. There are many more insights to be found in our report, so let’s dive in! Every year, JetBrains runs the Developer Ecosystem Survey to capture the landscape of the developer community, and this year’s results are finally in! One of the biggest trends of 2023 is AI usage gaining wider acceptance among software developers, with a whopping 77% of them using ChatGPT for various work-related tasks! In terms of programming languages, Objective-C is on its last legs, Rust set a new popularity record this year, and C++ and C are eighth and tenth, respectively, in the list of top languages. |
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